Signaling specifically from the endosome
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چکیده
منابع مشابه
Signaling specifically from the endosome
Take a big gulp of pox A poxvirus tricks cells into drinking it up, say Jason Mercer and Ari Helenius (Institute of Biochemistry, Zurich). Vaccinia, studied here, is a prototypical poxvirus, whose members also include the human smallpox virus. In studying how vaccinia enters cells, the authors observed that mature virus particles bound to fi lopodia and surfed toward the cell. After arriving at...
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Notch signaling is reliant on γ-secretase-mediated processing, although the subcellular location where γ-secretase cleaves Notch to initiate signaling remains unresolved. Accumulating evidence demonstrates that Notch signaling is modulated by endocytosis and endosomal transport. In this study, we investigated the relationship between Notch transport itinerary and signaling capacity. In doing so...
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Neurons are the largest cells in the body and form subcellular compartments such as axons and dendrites. During both development and adulthood building blocks must be continually trafficked long distances to maintain the different regions of the neuron. Beyond building blocks, signaling complexes are also transported, allowing for example, axons to communicate with the soma. The critical roles ...
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An emerging theme in cellular logistics is the close connection between mRNA and membrane trafficking. A prominent example is the microtubule-dependent transport of mRNAs and associated ribosomes on endosomes. This coordinated process is crucial for correct septin filamentation and efficient growth of polarised cells, such as fungal hyphae. Despite detailed knowledge on the key RNA-binding prot...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1814rr1